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P118: Heavy/Light Chain Immunoassays for Monitoring of a Multiple Myeloma Patient.

J. Radek1, P. Birkner1, I. Gruber1, D. Trubert-Exinger1

This study compared the performance of Hevylite with SPE and total immunoglobulin assays in the monitoring of a MM patient with a biclonal gammopathy (IgAk and IgGk).

Progression of the disease was detected by the IgGκ/IgGλ HLC ratio (due to suppression of IgGλ) earlier than by the other two methods.

Link to Radek – DGKL 2016

Please also find the following articles of interest attached:

De Santis E, Masi S, Cordone I, Pisani F, Zuppi C, Mattei F, et al. Follow-up of IgD-kappa multiple myeloma by monitoring free light chains and total heavy chain IgD: A case report. Oncol Lett 2016;12:1884-8.

Link to De Santis – Oncology Letters 2016


Gamundi Grimalt E, Morandeira Rego F, Clapes Puig V, Mestre Playa M, de la Banda Ledrado E, Sarra Escarre J. IgE multiple myeloma: a new case report. Clin Chem Lab Med 2016.

Link to Grimalt - CCLM 2016


Ramsden DB. ANNALS EXPRESS: Multiple Sclerosis: Assay of Free Immunoglobulin Light Chains. Ann Clin Biochem 2016.

Link to Ramsden – ACB 2016 final


van de Donk NW, Mutis T, Poddighe PJ, Lokhorst HM, Zweegman S. Diagnosis, risk stratification and management of monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. Int J Lab Hematol 2016;38 Suppl 1:110-22.

Link to van de Donk – Intl J Lab Hem 2016